Nanoparticles-Mediated Delivery of Herbal Extract: Impact on Inhibition Advanced Glycation End-Product (AGEs): A Systematic Review

Abstract. This systematic review compiles and analyzes research on the
therapeutic efficacy of nanoparticle-mediated delivery systems for herbal
extracts aimed at inhibiting the formation of Advanced Glycation Endproducts. A comprehensive search of PubMed and Google Scholar was
conducted in accordance with the PRISMA systematic review statement
guidelines included studies published within the past 10 years. Our
examination spans several studies utilizing different nanoparticle
formulations—such as gold, silver, and zinc oxide nanoparticles—and
encapsulated herbal extracts, including Poria cocos, Nigella sativa, and
curcumin, among others. The outcomes indicate that these nanocomplexes
not only foster enhanced delivery and bioavailability of the herbal extracts
but also significantly decrease inflammatory biomarkers and blood glucose
levels, enhance antioxidant responses, and protect against cellular damage
caused by oxidative stress. This review emphasizes the potential of
nanoparticles to augment the therapeutic properties of herbal medicines for
preventing and managing diabetic complications through the inhibition of
AGEs formation